[UPHPU] Deduping a list

[Ash]

I have a list of email addresses and a list of those who have 
unsubscribed. (We get a new list to send to every time from our partner, 
but we have to keep track of those who have unsubscribed from getting 
our emails, and remove them from the new list every time.)

So I have list 1 that has 10,000 email addresses in it and a list of 
unsubscribes that has about 200 email addresses. I want to remove all 
unsubscribes from the main list. Is there an easy way to do it?

Ash